Mitigation of radiation-induced lung injury by genistein and EUK-207
نویسندگان
چکیده
منابع مشابه
Establishment of a rat model of radiation-induced lung injury
Background: Radiation-induced lung injury is a refractory side effect in lung cancer radiotherapy, the mechanism still remains unclear, hence an appropriate animal mode may become useful to investigate it. Materials and Methods: 50 female Wistar rats were randomly divided into 5 groups, average 10 rats/cage: A. control group B. 3Gy×10f C. 6Gy×5f D. 12.5Gy×1f E.15.3Gy×1f....
متن کاملRadiation-induced Lung Injury
membrane, and are just wide enough to allow the passage of red blood cells, one cell at a time. The alveoli are lined with specialized epithelial cells termed Type I pneumocytes. Interspersed among these cells are surfactant-producing Type II pneumocytes. Within the alveolar wall, pneumocytes are separated from endothelial cells by their associated basement membranes and a potential stromal spa...
متن کاملestablishment of a rat model of radiation-induced lung injury
background: radiation-induced lung injury is a refractory side effect in lung cancer radiotherapy, the mechanism still remains unclear, hence an appropriate animal mode may become useful to investigate it. materials and methods: 50 female wistar rats were randomly divided into 5 groups, average 10 rats/cage: a. control group b. 3gy×10f c. 6gy×5f d. 12.5gy×1f e.15.3gy×1f. by different doses of r...
متن کاملSalen Mn complexes mitigate radiation injury in normal tissues.
Salen Mn complexes, including EUK-134, EUK-189 and a newer cyclized analog EUK-207, are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative stress. As oxidative stress is implicated in some forms of delayed radiation injury, we are investigating whether these compounds can mitigate injury to normal tissues caused by ionizing radiation. This review describes ...
متن کاملThe Evaluation of Melatonin Effect Against The Early Effect of Ionizing Radiation Induced Lung Injury
Background & Objective: Lung is a radiosensitive organ. Patients who are undergoing radiation therapy in their chest are subjected to radiation pneumonitis in the early phase and pulmonary fibrosis in the late one. Melatonin scavenges free radicals directly and acts as an indirect antioxidant through the activation of major antioxidant enzymes as well. The aim of the study thus is to investiga...
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ژورنال
عنوان ژورنال: International Journal of Radiation Biology
سال: 2011
ISSN: 0955-3002,1362-3095
DOI: 10.3109/09553002.2011.583315